Cancer & Personalized Tumor Models

What we study
 

We integrate patient-derived cancer organoids, organ-on-a-chip, biomaterials, and 3D bioprinting to reconstruct personalized tumor microenvironments. Our research focuses on understanding how the surrounding microenvironment regulates cancer progression and therapeutic response, including:
 

• Patient-specific tumor–microenvironment interactions

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• Extracellular matrix-dependent cancer adaptation

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• Tumor hypoxia and mechanical microenvironments

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• Cancer–immune interactions and immunotherapy responses

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• Metastatic colonization in tissue-specific microenvironments

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• Personalized prediction of anticancer drug responses

Our ultimate goal is to move beyond conventional patient-derived organoids toward personalized tumor ecosystems that reproduce both the intrinsic characteristics of a patient's cancer and the environmental conditions that determine its behavior.

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Supported Project

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• "Development of Microsystems for Safety Assessment of Immunotherapeutics"
  Korean ARPA-H Program, 2024–2029
   

• "CRISPR-Based Multi-Organ Mimetic Chip for Prediction of Metastasis Using Cancer Organoids"
  Basic Research Laboratory Program, 2021–2027