Publications

2026

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• H Yoon, D Kim, HJ Jeong, H Han, SJ Kim, J Jang, DB Jung, SJ Myung, CS Yu, IH Song, JH Choi, R Corces, T Kwon, K Myung, J Joo, JH Kang, TE Park*, SW Cho*. Tissue-derived extracellular matrix hydrogels instruct epigenetic adaptation in metastatic colonization, Bioactive Materials, 2027, DOI: 10.1016/j.bioactmat.2026.08.031

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• NK Lee, CPJ Wang, SH Lee, NY Chun, YJ Oh, U Batjargal, MS Kim, WJ Jang, HJ Kim, TE Park, W Park*, CG Park*, SN Kim*, Resiquimod-loaded MOF525 enables synergistic photodynamic therapy and immunotherapy for colorectal cancer, Nano Convergence, 2026, DOI: 10.1186/s40580-026-00544-2

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• B An, JW Kwon, H Yoon, TE Park, SW Yang, K Park*, Thermoreversible cell-derived extracellular matrix only hydrogel (CEOgel): development, characterization, and applications, Materials Today Bio, 2026, DOI: 10.1016/j.mtbio.2026.103040. ​

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• M Kim, K Kim, J Lee, S Lee, S Choi, SA Park, E Jeong, SY Choi, HH Park, TE Park, T Kwon, K Myung, J Yoo, SW Cho*, J Joo*, FAST‐CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid‐Silica Hybrid Nanoparticles for Therapeutic Genome Editing, Small, 2026, 22(15):e11362

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2025

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• H Lim, Kim D, H Yoon, JH Kang, YJ Kim, DS Kim*, TE Park*, Developmental hypoxia enhances kidney organoid complexity and maturity, Advanced Science, 2025,  12(40):e01661

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• H Ok, HS Park, J Park, S Hwang, J Jang, J Kim, G Park, D Park, TE Park*, C Kim*, JH Ryu*, A Self-Assembling Senolytic Prodrug with Enhanced Bioavailability and Selective Activation for Targeting  Senescent Retinal Pigment Epithelium, Biomaterials Research, 2025, 1(29):0261

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• ​D Kim, S Park, YR Kwon, H Yoon, BS Cho, I Baek, JH Kang, TE Park, MR Corces, HJ Kim, YJ Kim, SW Cho*, Analysis of chromatin accessibility associated with azacitidine response in higher-risk myelodysplastic neoplasms, iScience, 2025, 28(9):113297 

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• JH Choi, H Yoon, TE Park, JH Kang*, Endothelial layers cultured on an aligned fibrin matrix exhibit enhanced barrier integrity, Lab on a Chip, 2025, 25(18):4650

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• J Kim, X Zhang, R Wang, A Najer, QY Lau, A Cammack, JA Kim, YK Kang, R Xie, H Kim, K Xie, J Joo, TE Park, H Lim, MM Stevens*, Vascularized Human Heart-on-a-chip Platform for Modeling Myocardial Ischemia and Testing Nanomedicine Delivery Advanced Materials, 2025 DOI: 10.1002/adma.202418909

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• S Lee#, K Kim#, HJ Jeong#, S Choi, H Cheng, D Kim, So Heo, J Mun, M Kim, E Lee, YJ Choi, S Lee, EA Lee, Y Jang, K Lim, HS Kim, E Jeong, SJ Myung, DB Jung, CS Yu, IH Song, MR Corces, JH Kang ,K Myung, T Kwon, TE Park*, J Joo*, S Cho*, Efficient and precise targeting of cancer cells using multiplexed CRISPR/Cas9-nickase and PARP inhibitors, Cancer Research, 2025, 85(15):2890

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• J Han†,HJ Jeong†, J Choi, T Kwon, K Myung, K Park, JI Park, S Sanchez, DB Jung, CS Yu, IH Song, JH Shim, SJ Myung*, HW Kang*, TE Park *, Bioprinted Patient-derived Organoid Arrays Capture Intrinsic and Extrinsic Tumour Features for Advanced Personalised Medicine. Advanced Science, 2025,12(20):e2407871

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2024

• D Kim†,H Lim†, J Youn, TE Park *, DS Kim*, Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane. Nature Communications, 2024 DOI:10.1038/s41467-024-53073-z

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• TY  Kim†, Choi JW†, Park K, Kim SH, JF Kim, TE Park*, J Seo*, Lubricant-Coated Organ-on-a-chip for Enhanced Precision in Preclinical Drug Testing, Small, 2024 DOI:10.1002/smll.202402431
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• JW Choi†, K Kim†, K Mukhambetiyar, NK Lee, J Sabate del Rio, J Joo, CG Park, T Kwon*, TE Park*,  Organ-on-a-chip approach for accelerating blood-brain barrier nano-shuttle discovery, ACS Nano, 2024, 8(22): 14388

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• H Yoon, JH Kang, SW Cho, CG Park, DW Kim*, TE Park *, Brain decellularized ECM-based 3D myeloid sarcoma platform: mimicking adaptive phenotypic alterations in the brain, Advanced Healthcare Materials, 2024, 13(13):e2304371

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• H Yoon, J Sabaté del Río, SW Cho, TE Park *, Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism, Lab on a Chip, 2024, 24(5):1351

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• Wang, C.P.J, Ko, G.R., Lee, Y.Y., Park, J., Park, W., Park, T.E., Jin Y., Kim, S.N., Lee J.S., Park, C.G. Polymeric DNase-I nanozymes targeting neutrophil extracellular traps for the treatment of bowel inflammation, Nano Convergence, 2024, 11(6):1

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• M Zang, Z Zhang, H Li, Y Xia, M Xing, C Xiao, W Cai, L Bu, Y Li, TE Park, Y Tang, X Ye, WJ Lin, Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer's disease, Translational Neurogeneration, 2024, 13(1):1

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• SJ Park†, I Park†, S Kim†, MK Kim, S Kim, H Jeong, D Kim, SW Cho, TE Park, A Ni, H Lim, J Joo*, JH Lee *, JH Kang *, Extracorporeal Blood Treatment Using Functional Magnetic Nanoclusters Mitigates Organ Dysfunction of Sepsis in Swine, Small Method, 2024, doi.org/10.1002/smtd.20230142

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2023

• MJ Byun, HS Seo , J Lee, K Ban , S Oh, YY Lee, J Lim, NK Lee, CPJ Wang, M Kim, JH Han, J Park, T Paik, HH Park, TE  Park, SN Kim *, DH Park*, CG Park*, Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment, Small, 2023, 2304862

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• D Kim†,H Lim†, J Youn, TE Park *, DS Kim*, Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane. Research Square, doi.org/10.21203/rs.3.rs-3425714/v1

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• Lim H, Kim D, Yoon H, Kang JH, Kim DS*, Park TE*, A developmentally-inspired hypoxia condition promotes kidney organoid differentiation from human pluripotent stem cells. bioRxiv, doi: https://doi.org/10.1101/2023.07.29.551084

 

• Jeong HJ, Park JH, Kang JH, Sabate del Rio J, Kong SH*, Park TE*, Organoid-Based Human Stomach Micro-Physiological System to Recapitulate the Dynamic Mucosal Defense Mechanism, Advanced Science, 2023, 2300164

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• Yoon J, Rhyou J, Kim D, Lee J, Choi J, Park TE*, Kim DS*, Facile and adhesive-free method for bonding nanofiber membrane onto thermoplastic polystyrene substrate to fabricate 3D cell culture platforms. Materials Today Bio, 2023, 20, 100648

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• Jung SH, Jang BH, Kwon S, Park SJ, Park TE, Kang JH*, Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing. Advanced Materials, 2023, 13;e2211149

 

• Park J, Cho SW, Kang JH, Park TE*, Intestinal Peyer’s patches: structure, function, and in vitro modeling. Tissue Engineering and Regenerative Medicine, 2023, 20, 1

 

• Choi JW†, Seo M†, Kim K, Kim AR, Lee H, Kim HS, Park CG, Cho SW, Kang JH, Joo J*, Park TE*, Aptamer nano-constructs crossing human blood-brain barrier discovered via microphysiological system-based SELEX technology. ACS Nano, 2023, 17, 8153

 

• Yoon H, Park TE*,  Engineered adipose tissue platforms: recent breakthroughs and future perspectives. Organoid, 2023, 3, 1

 

• Yoon H, Seo JK, Park TE*,  Microphysiological system recapitulating the pathophysiology of adipose tissue in obesity, Acta Biomaterialia, 2023, 159, 188

 

• Sabate del Rio J, Ro J, Yoon H, Park TE*, Cho YK*,  Integrated technologies for continuous monitoring of organ-on-a-chip: current challenges and potential solutions. Biosensors and Bioelectronics, 2023, 224, 115057

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• Choi JW†, Yoon J†, Kim DS*, Park TE*, Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane. Biomaterials, 2023, 293, 121983

 

2022

• Ahn J, Kim DH, Koo DJ, Lim J, Park TE, Lee J, Ko J, Kim S, Kim M, Kang KS, Min DH, Kim SY, Kim YT*, Jeon NL*, 3D microengineered vascularized tumor spheroids for drug delivery and efficacy testing, Acta Biomaterialia, 2022

 

• JH Han, YY Lee, HE Shin, J Han, JM Kang , C-P J Wang , JH Park, SN Kim, JH Yoon, HK Kwon, DH Park , TE Park, YB Choy, DH Kim, TH Kim, J Min, IH Kim, CG Park*, DK Han*, W Park*,  Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique, Biomaterials, 2022, 289

 

• Islam MA†, Park TE†, Firdous J, Li HS, Jimenez Z, Lim M, Choi JW, Yun CH*, Cho CS*, Essential cues of engineered polymeric materials regulating gene transfer pathways, Progress in Materials Science, 2022, 128

 

• Kim HS, Seo MW, Park TE, Lee DY*, A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy, Journal of Nanobiotechnology, 2022, 20, 1

 

• Jeong HJ, Park JH, Kang JH, Kong SH, Park TE* , Organoid-based human stomach micro-physiological system to recapitulate the dynamic mucosal defense mechanism, Biorxiv, 2022 https://doi.org/10.1101/2022.03.02.482603

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2021

• Choi B†, Choi JW†, Jin H, Sim HR, Park JH, Park TE*, Kang JH*, Condensed ECM-based nanofilms on highly permeable PET membranes for robust cell-to-cell communications with improved optical clarity, Biofabrication, 2021, 13, 4

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• Seo MW, Park TE*, Recent advances with liposomes as drug carriers for treatment of neurodegenerative diseases, Biomedical Engineering Letter, 2021, 11, 3

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• Choi G, Ko H, Jang H, Hwang I, Seong M, Sun K, Park HH, Park TE, Kim J, Jeong HE*, Biofouling-resistant tubular fluidic devices with magneto-responsive dynamic walls, Soft Matter, 2021, 21, 17

 

2020

• Lee J, Park J, Kim J, Lee G, Park TE, Yoon K, Kim YK, Lim C*, LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient, PLoS Biology, 2020, 18, 12

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• Novak R et al., Robotic fluidic coupling and interrogation of multiple vascularized organ chips, Nature Biomedical Engineering, 2020, 4, 407

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• Jeong HJ, Jimenez Z, Mukhambetiyar K, Seo M, Choi JW, Park TE*, Engineering human brain organoids: from basic research to tissue regeneration, Tissue Engineering and Regenerative Medicine, 2020, 7, 747

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• Khim KK, Choi SS, Jang HJ, Lee YH, Lee E, Hyun JM, Eom HJ, Yoon S, Choi JW, Park TE, Nam D, Choi JH*, PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273, Cells, 2020, 9, 343

 

2019

• Park TE, Mustafaoglu N, Herland A, Hasselkus R, Mannix R, FitzGerald EA, Prantil-Baun R, Watters A, Henry O, Benz M, Sanchez H, McCrea HJ, Goumnerova LC, Song HW, Palecek SP, Shusta E, and Ingber DE*, Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies, Nature Communications, 2019, 13, 10(1):2621

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• Park S, Park H, Sun K, Gwon Y, Seong M, Kim S, Park TE, Hyun H, Choung YH, Kim J, Jeong HE*, Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior, ACS Nano, 2019

 

• Morad G, Carman CV, Hargedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy C, Moses MA*, Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis,  ACS Nano, 2019

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• Ahn J, Lim J, Jusoh N, Lee J, Park TE, Kim YT, Kim J*, Jeon NL*, 3D microfluidic bone TME comprised of hydroxyapatite/fibrin composite, Frontiers in Bioengineering and Biotechnology, 2019, 17, 168

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• Nguyen T, Jung SH, Lee MS, Park TE, Ahn S*, Kang JH*, Robust chemical bonding of PMMA microfluidic devices to porous PETE membranes for reliable cytotoxicity testing of drugs, Lab on a Chip, 2019, 19, 3706

 

2018

• Ahn J, Cho CS, Cho SW, Kang JH, Kim SY, Min DH, Song JM, Park TE*, Jeon NL*, Investigation on vascular cytotoxicity and extravascular transport of cationic polymer nanoparticles using perfusable 3D microvessel model, Acta Biomateriallia, 2018, 76, 154-163

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• Maoz B, Herland A, FitzGerald EA, Grevesse T, Vidoudez C, Pacheco AR, Sheehy SP, Park TE, Dauth S, Mannix R, Budnik N, Shores K, Cho A, Nawroth JC, Segrè D, Budnik B, Ingber DE*, Parker KK*. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells, Nature Biotechnology, 2018, 36, 865-875

 

~2017(selected)

• Herland, A., van der Meer AD, FitzGerald, E.A., Park, T.E., Sleeboom, J.J., Ingber, D.E., Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip, PLoS ONE. 2016, 11(3):e0150360

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• Park TE, Singh B, Li H, Lee JY, Kang SK, Choi YJ, Cho CS. Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer’s disease, Biomaterials, 2015, 38(3) 61-71

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• Kim YD#, Park TE#, Sing B, Maharjan S, Choi YJ., Choung H, Arote R*, Cho CS*. Nanoparticle-mediated delivery of siRNA for effective lung cancer therapy, Nanomedicine, 2015, 10(7), 1165-118

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• Islam MA#, Park TE#, Sing B, Maharjan S, Firdous J, Cho MH, Kang SK, Yun CH, Choi YJ, Cho CS. Major degradable polycations as carriers for DNA and siRNA, Journal of Controlled Release, 2014, 193(10) 74-89

 

• Park, T.E., Kang, B., Kim, Y.K., Zhang, Q., Lee, W.S., Islam, M.A., Kang, S.K., Cho, M.H., Choi, Y.J.,  Cho,  C.S.  Selective  stimulation  of  caveolae-mediated  endocytosis  by  an  osmotic polymannitol-based gene transporter, Biomaterials, 2012, 33(29) 7272-7281