What we study

We develop human aging MPS models that reconstruct key features of tissue and organ aging in controlled experimental environments. These platforms allow us to identify previously inaccessible mechanisms of human aging and discover molecular or therapeutic strategies capable of restoring aged tissue function.

Our current projects particularly focus on:
 

• Brain vascular aging and age-associated impairment of blood–brain barrier function

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• Brain lymphatic and glymphatic aging, including age-dependent impairment of cerebrospinal fluid and brain waste clearance

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• Immune aging and its contribution to age-associated tissue dysfunction and disease

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• Development of integrated human aging MPS platforms for evaluating the efficacy and safety of rejuvenation therapies

Ultimately, we aim to establish human MPS as a translational platform for understanding how aging emerges across multiple biological scales and for discovering strategies that restore tissue homeostasis.

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Supported Project

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• "Human Glymphatic System-on-a-Chip for Identifying Strategies to Enhance Brain Waste Clearance"

          NRF Early-Career Researcher Program, 2025–2029

• "Development of a Multi-Omics–AI Integrated Preclinical Platform for Aging Intervention Based on Complex Human In Vitro Aging Models", Next-Generation Bio Program, 2026–2030